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Brain plaques may appear decades before Alzheimer's symptoms manifest


Anomalous agglomerations of β-amyloid protein may appear in the brain up to 30 years before people develop Alzheimer's disease, a new study has found. The new study also confirms that brain plaques become more and more common as they get older, even though memory and thought remain intact.

The researchers conducted a meta-analysis and in total included in their study nearly 3,000 adults with normal memory and thinking abilities and almost 4,000 with mild cognitive impairment, all of them in an age range of 18-100 years and who had undergone A positron emission tomography scan or a sample of cerebrospinal fluid.

Among people with intact mental abilities, brain plaques became more and more common with age. Ten percent of 50-year-olds had deposits of β-amyloid, a figure that reached 33 percent at age 80 and 44 percent at age 90. The figures were two or three times higher among the carriers of the genetic variant APOE4, which increases the risk of Alzheimer's disease.
People with milder memory problems had a higher prevalence of brain plaques than their peers with keen minds: almost 30% of those aged 50, almost 50% of those aged 70 and 60% of the Of 80 years.

http://www.neurologia.com/sec/...   http://jama.jamanetwork.com/ar...

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